Design and Development of Pharmaceutical Formulations

 Design and optimization of nano-scale drug carriers to improve stability, solubility, and targeting therapeutics. We develop a variety of nanocarriers — from polymeric nanoparticles and dendrimers to vesicular systems like liposomes and niosomes, lipid-based carriers such as solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and nanoemulsions, as well as nanogels and hybrid nanoparticles. These nanosystems can significantly improve the solubility of poorly water-soluble compounds and enable targeted delivery of payloads. 

 Formulation techniques to increase the aqueous solubility of challenging drug candidates, ensuring sufficient bioavailability. We employ approaches such as particle size reduction (micronization/nanonization), use of solubilizing excipients (surfactants, cyclodextrins), lipid-based formulations, and pH adjustment to dissolve hydrophobic compounds. By improving dissolution rate and solubility, these strategies help maximize absorption of the drug. 

 Development of targeted drug delivery technologies and controlled-release formulations to direct therapeutics to specific sites and modulate drug release kinetics. This approach minimizes systemic exposure and side effects by concentrating the drug at the intended site of action, and it can prolong drug action through sustained release or improved pharmacokinetic profiles. Formulation science can thus be leveraged to optimize a drug’s absorption, distribution, metabolism, and excretion characteristics, enhancing its overall pharmacokinetic profile and therapeutic index. 

 Comprehensive physico-chemical and in vitro evaluation of formulations. We measure particle size and zeta potential (indicators of colloidal stability) for nanoparticulate systems, determine drug loading and encapsulation efficiency, and perform in vitro drug release profiling to predict how the formulation will behave in vivo. For topical and transdermal formulations, we conduct skin deposition and permeation studies to assess how effectively the drug penetrates the skin. These analytical assays ensure that each formulation meets the desired specifications for stability, release kinetics, and delivery performance. 

 Unlike many others, the ViveGen team is firmly committed to its core value of driving every project toward successful outcomes. We don’t simply deliver data and walk away—we stay engaged and responsive throughout the process, ensuring that each new formulation is refined and optimized until it aligns seamlessly with your research objectives. Our unwavering dedication, scientific expertise, and collaborative spirit mean we remain by your side until your goals are fully achieved and exceeded.